Before diving into the subject of what PDO Threads are, it is helpful to first have an understanding of the effect they produce. In short, PDO Threads trigger a foreign body reaction from your body. The reaction results in the natural production of collagen and elastin. Here is a closer look how it works!

Neocollagenesis and Neoelastinogenesis

extracellular matrix
source: OpenStax Biology

Collagen and elastin are the main fibers that form the extracellular matrix. Both are formed by fibroblasts. Collagen is responsible for tensile strength and elastin provides elasticity to the skin. Production and density of both decreases as a function of age, and results in sagging and wrinkling. Wounding alters the amount and quality of these fibers. Thus, neocollagenesis and neoelastinogenesis hold the key to managing aesthetic conditions such as cutaneous ageing and scarring.

What are PDO Threads?

This isn’t the latest Internet emoji. It depicts the chemical structure of Polydioxanone (PDS) –  a colourless, crystalline, biodegradable synthetic polymer.

PDS is most commonly known for and used as suture material. All sutures, regardless of their composition, are foreign materials and elicit a foreign body reaction in the body.

After administering a local anesthetic, PDO Threads are introduced to the target areas by way of a fine needle.

The Effects

PDS sutures cause minimal tissue reaction, and, stimulate the activity of fibroblasts, thus activating the mechanism of neocollagenesis.

The long-term effect is exactly what you want it to be! Absorption of the suture is through a process called hydrolysis and happens within 180 days from implantation day. 

It has been histologically confirmed that within the 1st month a delicate fibrous capsule forms around the implanted threads. It coats the threads as a small soft connective tissue cover, creating artificial ligaments that strengthen the effect achieved after the thread introduction. As a result, there has been noted a double effect of absorbable threads usage – consistent mechanical lift effect and tissue revitalization.